| J Pharmacobiodyn 1991 Jul;14(7):371-5
Effects of dietary konjac
mannan on serum and liver cholesterol levels and biliary bile
acid composition in hamsters.
Shimizu H, Yamauchi M, Kuramoto T, Kubota N, Matsuda M, Hoshita
Institute of Pharmaceutical Science, Hiroshima University School
of Medicine, Japan.
We studied the effect of dietary konjac mannan on serum and
liver cholesterol levels and biliary bile acid composition in
hamsters. In hamsters fed a control diet supplemented with konjac
mannan for 6 weeks, serum and liver cholesterol levels were
decreased significantly compared to hamsters fed the control
diet. Addition of konjac mannan to the cholesterol-enriched
diet reduced the elevation of serum cholesterol caused by feeding
cholesterol. However, the absorption of cholesterol from the
intestine was not changed between the four groups. The increase
in the proportion of chenodeoxycholic acid in biliary bile acids
was significantly enhanced in the hamsters fed both cholesterol
and konjac mannan compared to hamsters fed the control diet.
The change of the bile acid composition may suggest that konjac
mannan inhibits the intestinal absorption of bile acids.