| Minerva Ginecol 1996 Dec;48(12):577-82
A clinical study of the
use of a combination of glucomannan with lactulose in the constipation
[Article in Italian]
Signorelli P, Croce P, Dede A.
Divisione di Ostetricia e Ginecologia, Ospedale di Codogno,
Regione Lombardia, USL n. 25, Lodi.
RATIONAL: Constipation is a problem frequently encountered during
pregnancy as is excessive weight gain. Treatments of common
use to control constipation are endowed with some drawbacks
and they are not active in controlling weight increase. A preparation
of lactulose and glucomannan in previous studies proved very
effective and well tolerated in patients affected by stypsis
and evidentiated also activity both in controlling excessive
food intake and in correcting some metabolic imbalances regarding
lipids and urea. MATERIAL AND METHODS: 50 pregnant females affected
by constipation were treated with sachets containing a preparation
of glucomannan (1.45 g) and lactulose (4.2 g) in a posology
of 2 (1-4) sachets a day for 1-3 months. RESULTS: Treatment
induced a return to normal frequency of weekly number of evacuations
(4.9-5.8/week) and a parallel control of weight gain (within
20% of initial body weight). The latter finding seems to be
related to hunger control induced by glucomannan at the gastric
level which prevents an excessive food intake.