The most viscosity soluble fiber in nature
Konjac Glucomannan

Effect of soluble fiber intake in lipid and glucose levels in healthy subjects: a randomized clinical trial.

Diabetes Res Clin Pract. 2004 Jul;65(1):7-11.
Aller R, de Luis DA, Izaola O, La Calle F, del Olmo L, Fernandez L, Arranz T, Hernandez JM.
Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, C/Los Perales 16 (URB Las Acenas), Simancas, 47130 Valladolid, Spain.

The aim of our work was to carry out a randomized clinical trial with two diets, one enriched in fiber (total fiber 30 g and soluble fiber 4 g) to investigate the effect on lipid and glucose levels in healthy subjects.

Fifty-three subjects were prospectively randomized to two groups (see Table 1). Group I received a diet with 10.4 g of fiber given as 1.97 g soluble fiber (pectins, gums and mucilages) and 8.13 g of insoluble fiber (hemicelullose, cellulose and lignins) and Group II received a diet with 30.5 g of fiber of which 4.11 g were soluble fiber and 25.08 g insoluble fiber. Prospective serial assessment of weight and nutritional intake (3 days written food records) were made. These determinations were performed at baseline and at 3 months. All enrolled subjects underwent the following examinations; fasting blood samples were drawn for measurement of total cholesterol, triglyceride concentrations and other lipid fractions, low density lipoprotein (LDL-cholesterol), high density lipoprotein (HDL-cholesterol), glucose, and insulin. RESULTS: Total calorie and fat consumption were lower than recommended in both groups (calories; group I 1633+/-417 kcal per day versus group II 1707.5 +/- 579 kcal per day:ns) and (fats; group I 73.4 +/- 22.7 g per day versus group II [72.6 +/- 28 g per day:ns), without differences in fatty acid intake profile. Total fiber intake did not reach that recommended in both diets but it was higher in group II ( 9.06 +/- 2.7 g per day versus 25.95 +/- 7.12 g per day: P < 0.05). Soluble fiber intake did not reach that recommended in both diets but it was higher in group II (1.7 +/- 0.58 g per day versus 3.5 +/- 0.96 g per day: P < 0.05). Body weight did not change in both groups during treatment. During treatment, in group II a significant change was detected from baseline in LDL-cholesterol and fasting glucose levels. LDL-cholesterol decreased by 12.8% (P < 0.05) and glucose decreased by 12.3% (P < 0.05). No statistical differences were detected among triglycerides, HDL-cholesterol, and insulin levels.


Modest increases in soluble fiber intake in healthy subjects improved LDL cholesterol and glucose levels.

Publication Types:
Clinical Trial
Randomized Controlled Trial



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