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| Int J Cancer 2001 Feb 1;91(3):283-7 |
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Fiber
intake and the risk of oral, pharyngeal and esophageal cancer.
Soler M, Bosetti C, Franceschi S, Negri E, Zambon P, Talamini
R, Conti E, La Vecchia C.
Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy.
The relation between various types of fiber and oral, pharyngeal
and esophageal cancer was investigated using data from a case-control
study conducted between 1992 and 1997 in Italy. Cases were 271
hospital patients with incident, histologically confirmed oral
cancer, 327 with pharyngeal cancer and 304 with esophageal cancer.
Controls were 1,950 subjects admitted to the same network of
hospitals as the cases for acute, nonneoplastic diseases. Cases
and controls were interviewed during their hospital stay using
a validated food frequency questionnaire. Odds ratios (OR) were
computed after allowance for age, sex, and other potential confounding
factors, including alcohol, tobacco consumption, and energy
intake. The ORs for the highest vs. the lowest quintile of intake
of oral, pharyngeal and esophageal cancer combined were 0.40
for total (Englyst) fiber, 0.37 for soluble fiber, 0.52 for
cellulose, 0.48 for insoluble non cellulose polysaccharide,
0.33 for total insoluble fiber and 0.38 for lignin. The inverse
relation were similar for vegetable fiber (OR = 0.51), fruit
fiber (OR = 0.60) and grain fiber (OR = 0.56), and were somewhat
stronger for oral and pharyngeal cancer than for esophageal
cancer. The ORs were similar for the two sexes and strata of
age, education, alcohol and tobacco consumption, and total non-alcohol
energy intake. Our study indicates that fiber intake may have
a protective role on oral, pharyngeal and esophageal cancer.
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